Bullous pemphigoid following therapy with an oral beta-blocker

J Drugs Dermatol. 2005 Nov-Dec;4(6):746-8.


A causal relationship is thought to exist between several medications and the development of bullous pemphigoid. Commonly implicated medications include furosemide, penicillins, and ibuprofen. The following is a case report of an elderly man who developed generalized bullous pemphigoid for the first time after beginning therapy with an oral beta-blocker. A literature search revealed only 2 other reports of beta-blocker associated bullous pemphigoid. As both bullous pemphigoid and beta-blockers are common in elderly patients, dermatologists may want to consider beta-blockers as potential etiological agents in the development of bullous pemphigoid.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Adrenergic beta-Antagonists / administration & dosage
  • Adrenergic beta-Antagonists / adverse effects*
  • Aged, 80 and over
  • Dermatologic Agents / therapeutic use
  • Drug Administration Schedule
  • Humans
  • Male
  • Metoprolol / administration & dosage
  • Metoprolol / adverse effects*
  • Mycophenolic Acid / analogs & derivatives
  • Mycophenolic Acid / therapeutic use
  • Pemphigoid, Bullous / chemically induced*
  • Pemphigoid, Bullous / drug therapy
  • Prednisone / therapeutic use
  • Time Factors
  • Treatment Outcome


  • Adrenergic beta-Antagonists
  • Dermatologic Agents
  • Metoprolol
  • Mycophenolic Acid
  • Prednisone