Gc protein (vitamin D-binding protein): Gc genotyping and GcMAF precursor activity

Anticancer Res. Nov-Dec 2005;25(6A):3689-95.


The Gc protein (human group-specific component (Gc), a vitamin D-binding protein or Gc globulin), has important physiological functions that include involvement in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5a for neutrophils in inflammation and macrophage activation (mediated by a GalNAc-modified Gc protein (GcMAF)). In this review, the structure and function of the Gc protein is focused on especially with regard to Gc genotyping and GcMAF precursor activity. A discussion of the research strategy "GcMAF as a target for drug discovery" is included, based on our own research.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Drug Design
  • Genotype
  • Humans
  • Macrophage-Activating Factors / immunology
  • Macrophage-Activating Factors / metabolism
  • Macrophage-Activating Factors / pharmacology
  • Macrophage-Activating Factors / physiology*
  • Molecular Sequence Data
  • Protein Structure, Tertiary
  • Structure-Activity Relationship
  • Vitamin D-Binding Protein / chemistry*
  • Vitamin D-Binding Protein / genetics
  • Vitamin D-Binding Protein / immunology
  • Vitamin D-Binding Protein / metabolism
  • Vitamin D-Binding Protein / pharmacology
  • Vitamin D-Binding Protein / physiology*


  • Macrophage-Activating Factors
  • Vitamin D-Binding Protein
  • vitamin D-binding protein-macrophage activating factor