Role of surfactant protein D (SP-D) in innate immunity in the gastric mucosa: evidence of interaction with Helicobacter pylori lipopolysaccharide

J Endotoxin Res. 2005;11(6):357-62. doi: 10.1179/096805105X76832.


Surfactant protein D (SP-D) is a collagenous glycoprotein, a collectin, which functions as a pathogen-associated molecular pattern (PAMP) recognition receptor in the innate immune response. Although originally identified in the lung as a component of surfactant, SP-D also occurs in the gastric mucosa at the luminal surface and within gastric pits of mucus-secreting cells. Infection with the gastroduodenal pathogen Helicobacter pylori up-regulates expression of SP-D in human patients with gastritis, and its influence on colonization has been demonstrated in a Helicobacter SP-D-deficient (SP-D(-/-)) mouse model. SP-D binds and agglutinates H. pylori cells in a lectin-specific manner, and has been shown to bind H. pylori lipopolysaccharide. Furthermore, evidence indicates that H. pylori varies LPS O-chain structure to evade SP-D binding which is speculated aids persistence of this chronic infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Gastric Mucosa / immunology*
  • Gastritis / immunology
  • Gastritis / microbiology
  • Helicobacter pylori / chemistry
  • Helicobacter pylori / immunology*
  • Immunity, Innate*
  • Lipopolysaccharides / immunology*
  • Models, Biological
  • Pulmonary Surfactant-Associated Protein D / immunology*


  • Lipopolysaccharides
  • Pulmonary Surfactant-Associated Protein D
  • lipopolysaccharide, Helicobacter pylori