IL-7: a key regulator of B lymphopoiesis

Semin Immunol. 2006 Feb;18(1):20-30. doi: 10.1016/j.smim.2005.10.003. Epub 2005 Nov 21.

Abstract

Interleukin-7 plays important roles in the B cell developmental pathway including events leading to commitment, survival, proliferation, and maturation. Because of its central role in adult murine B lymphopoiesis, IL-7 is frequently used to generate B cell progenitors in vitro. We have shown that differentiation of IL-7-responsive cells in these cultures is influenced by CD45, pre-B cell receptor, and other downstream signaling molecules. A common, but often overlooked aspect of IL-7 containing cultures is the routine maturation of cells to the sIgM(+) stage. The production of B cells in IL-7 containing cultures is balanced by cell death, since such cells fail to survive for long without additional stimulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / cytology*
  • B-Lymphocytes / physiology*
  • Cell Differentiation / physiology*
  • Humans
  • Interleukin-7 / physiology*
  • Lymphopoiesis / physiology*
  • Signal Transduction / immunology

Substances

  • Interleukin-7