A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi

Antimicrob Agents Chemother. 2005 Dec;49(12):5160-1. doi: 10.1128/AAC.49.12.5160-5161.2005.

Abstract

Cruzain is an essential cysteine protease of Trypanosoma cruzi and a therapeutic target for Chagas' disease. Eight dogs were infected with T. cruzi; three were treated with an inhibitor of cruzain, K777, for 14 days. Treatment with K777 abrogated myocardial damage by T. cruzi, as documented by histopathological lesion scores and serum troponin I levels.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chagas Disease / complications*
  • Chagas Disease / drug therapy
  • Cysteine Endopeptidases / drug effects*
  • Cysteine Proteinase Inhibitors / therapeutic use*
  • Dogs
  • Heart Arrest / etiology
  • Heart Arrest / prevention & control*
  • Protozoan Proteins* / drug effects
  • Trypanosoma cruzi / drug effects*

Substances

  • Cysteine Proteinase Inhibitors
  • Protozoan Proteins
  • Cysteine Endopeptidases
  • cruzain, Trypanosoma cruzi