Antisperm vaccine for contraception

Am J Reprod Immunol. 2005 Dec;54(6):378-83. doi: 10.1111/j.1600-0897.2005.00331.x.


Problem: This study is a review of antisperm contraceptive vaccine (CV) development with the main focus on research going on in our laboratory.

Method of study: Various methods of proteomics and genomics, hybridoma technology, substractive libraries, differential display method, and phage display technology were used to obtain sperm-specific genes and proteins. The present study will primarily focus on the sequences obtained by using the phage display technology and their role in CV development and human immunoinfertility.

Result: Four novel peptides, delineated by using the phage display technology, were found to be involved in human immunoinfertility. The vaccine based on one of these peptides, designated as YLP(12), caused a reversible contraception in female mice.

Conclusions: The vaccine targeting sperm is a feasible and exciting approach to contraception. The phage display technology is a powerful tool to delineate sperm-specific peptide sequences that can be used for the CV development and in the diagnosis and treatment of infertility mediated through antisperm antibodies.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Contraception* / methods
  • Female
  • Humans
  • Male
  • Mice
  • Peptide Fragments / immunology*
  • Peptide Fragments / pharmacology
  • Spermatozoa / drug effects
  • Spermatozoa / immunology*
  • Vaccines, Contraceptive / immunology*
  • Vaccines, Contraceptive / pharmacology


  • Peptide Fragments
  • Vaccines, Contraceptive