Effect of caffeine on the body fat and lipid metabolism of rats fed on a high-fat diet

Biosci Biotechnol Biochem. 2005 Nov;69(11):2219-23. doi: 10.1271/bbb.69.2219.


The intake of caffeine (CF) at 0.025, 0.05 or 0.1% for 21 days progressively reduced the body fat mass and body fat percentage in Sprague-Dawley (SD) rats fed on a high-fat diet with increasing administration level. Moreover, CF increased the serum concentrations of catecholamines and free fatty acids in SD rats orally administered with CF (5 mg/kg). These results suggest that the intake of CF reduced body fat by lipolysis via catecholamines. CF has potential as a functional food ingredient with an anti-obesity action.

MeSH terms

  • Adipose Tissue / drug effects*
  • Animals
  • Body Composition
  • Body Weight / drug effects
  • Caffeine / administration & dosage
  • Caffeine / pharmacology*
  • Catecholamines / blood
  • Dietary Fats / administration & dosage*
  • Dose-Response Relationship, Drug
  • Fatty Acids / blood
  • Lipid Metabolism / drug effects*
  • Lipolysis
  • Male
  • Obesity / drug therapy
  • Rats
  • Rats, Sprague-Dawley


  • Catecholamines
  • Dietary Fats
  • Fatty Acids
  • Caffeine