Insights into the acclimation of Chlamydomonas reinhardtii to sulfur deprivation

Photosynth Res. 2005 Dec;86(3):475-89. doi: 10.1007/s11120-005-4048-9. Epub 2005 Nov 15.


During sulfur deprivation, the photosynthetic green alga Chlamydomonas reinhardtii develops a high-affinity sulfate uptake system and increases the expression of genes encoding proteins involved in sulfur assimilation. Although two regulatory elements, SAC1 and SAC3, have been shown to be required for normal acclimation of C. reinhardtii to sulfur deprivation, a number of other regulatory elements appear to also be involved. The molecular mechanisms by which these regulatory elements function are largely unknown. This manuscript presents our current knowledge of sulfur deprivation responses and the regulation of these responses in C. reinhardtii. In addition, we present preliminary results of a sub-saturation screen for novel sulfur acclimation mutants of C. reinhardtii. A speculative model, incorporating the activities of established regulatory elements with putative novel components of the signal transduction pathway(s) is discussed.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Acclimatization / physiology*
  • Animal Nutritional Physiological Phenomena
  • Animals
  • Biological Transport
  • Chlamydomonas reinhardtii / drug effects*
  • Chlamydomonas reinhardtii / metabolism
  • Chlamydomonas reinhardtii / physiology*
  • Protozoan Proteins / chemistry
  • Protozoan Proteins / genetics
  • Protozoan Proteins / metabolism
  • Sulfur / pharmacology*


  • Protozoan Proteins
  • Sulfur