Chemical genetics: Drug screens in Zebrafish

Biosci Rep. Oct-Dec 2005;25(5-6):289-97. doi: 10.1007/s10540-005-2891-8.


High throughput chemical genetic screens for compounds with specific biological activity in a whole organism are feasible using zebrafish embryos. At least two medium to large scale drug screens have been carried out to date, leading to the identification of compounds that disturb zebrafish development. Chemical genetics using zebrafish embryos may become an important step in the discovery of drugs and their targets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Drug Evaluation, Preclinical / methods*
  • Models, Biological
  • Models, Genetic
  • Mutagenesis
  • Pharmacogenetics / methods*
  • Toxicity Tests
  • Zebrafish / embryology
  • Zebrafish / metabolism*
  • Zebrafish / physiology*