Corticosteroids after preterm premature rupture of membranes

Obstet Gynecol Clin North Am. 1992 Jun;19(2):317-26.


A review of all relevant randomized controlled trials provides strong evidence that corticosteroid therapy causes a significant reduction in respiratory distress syndrome (RDS) in preterm babies overall. This reduction in RDS is accompanied by a reduced incidence of neonatal death, intraventricular hemorrhages, and necrotizing enterocolitis. These benefits are also seen in cases of PROM. Corticosteroid therapy in PROM is associated with a trend toward an increase in neonatal infection.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Review

MeSH terms

  • Adrenal Cortex Hormones / adverse effects
  • Adrenal Cortex Hormones / therapeutic use*
  • Female
  • Fetal Membranes, Premature Rupture / complications*
  • Humans
  • Infant, Newborn
  • Pregnancy
  • Pregnancy Complications, Infectious / etiology
  • Randomized Controlled Trials as Topic
  • Respiratory Distress Syndrome, Newborn / embryology
  • Respiratory Distress Syndrome, Newborn / prevention & control*


  • Adrenal Cortex Hormones