Virucidal activity of a new hand disinfectant with reduced ethanol content: comparison with other alcohol-based formulations

J Hosp Infect. 2006 Jan;62(1):98-106. doi: 10.1016/j.jhin.2005.06.020. Epub 2005 Nov 22.

Abstract

A new formula with reduced ethanol content (55%) in combination with 10% propan-1-ol, 5.9% propan-1.2-diol, 5.7% butan-1.3-diol and 0.7% phosphoric acid exhibited a broad spectrum of virucidal activity. In quantitative suspension tests, with and without protein load, this formulation reduced the infectivity titre of seven enveloped (influenza A and B, herpes simplex 1 and 2, bovine corona, respiratory syncytial, vaccinia, hepatitis B, bovine viral diarrhoea) and four non-enveloped (hepatitis A, polio, rota, feline calici) viruses >10(3)-fold within 30s. In comparative testing, only 95% ethanol showed similar levels of activity. In fingerpad tests, the formulation produced a log10 reduction factor of the titre of poliovirus type 1 (Sabin) of 3.04 in 30s compared with 1.32 by 60% propan-2-ol. Testing against feline calicivirus produced a log10 reduction factor of 2.38 by the test formulation; in contrast, the log10 reduction factors with 70% ethanol and 70% propan-1-ol were 0.68 and 0.70, respectively.

MeSH terms

  • 1-Propanol / analysis
  • Adult
  • Animals
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Butanols / analysis
  • Calicivirus, Feline / drug effects
  • Cats
  • Cattle
  • Cell Line
  • Disinfectants / chemistry
  • Disinfectants / pharmacology*
  • Drug Synergism
  • Ethanol / analysis*
  • Female
  • Fingers / virology
  • Hand Disinfection / methods*
  • Humans
  • Male
  • Phosphoric Acids / analysis
  • Poliovirus / drug effects
  • Propylene Glycol / analysis
  • Viruses / drug effects*

Substances

  • Antiviral Agents
  • Butanols
  • Disinfectants
  • Phosphoric Acids
  • Ethanol
  • Propylene Glycol
  • 1-Propanol
  • phosphoric acid