An essential connection: link between Hsp70's domains at last

Mol Cell. 2005 Nov 23;20(4):493-4. doi: 10.1016/j.molcel.2005.11.007.


Communication between the ATPase and substrate binding domains of Hsp70 is critical for regulated interaction between this molecular chaperone and its client proteins. In this issue of Molecular Cell, Jiang et al. (2005) report the structure of an intact Hsp70, revealing critical interactions between the two domains.

Publication types

  • Comment

MeSH terms

  • Animals
  • HSP70 Heat-Shock Proteins / chemistry*
  • HSP70 Heat-Shock Proteins / physiology*
  • Humans
  • Protein Structure, Tertiary


  • HSP70 Heat-Shock Proteins