GOAT: An R Tool for Analysing Gene Ontologytrade mark Term Enrichment

Appl Bioinformatics. 2005;4(4):281-3. doi: 10.2165/00822942-200504040-00008.


Understanding the composition of gene lists that result from high-throughput experiments requires elaborate processing of gene annotation lists. In this article we present GOAT (Gene Ontology Analysis Tool), a tool based on the statistical software 'R' for analysing Gene Ontologytrade mark (GO) term enrichment in gene lists. Given a gene list, GOAT calculates the enrichment and statistical significance of every GO term and generates graphical presentations of significantly enriched terms. GOAT works for any organism with a genome-scale GO annotation and allows easy updates of ontologies and annotations.

Availability: GOAT is freely available from http://dictygenome.org/software/GOAT/ CONTACT: Gad Shaulsky (gadi@bcm.tmc.edu).