Microbial transformation of silybin by Trichoderma koningii

Bioorg Med Chem Lett. 2006 Feb 15;16(4):790-3. doi: 10.1016/j.bmcl.2005.11.022. Epub 2005 Nov 23.

Abstract

Microbial transformation of silybin A (1) and silybin B (2), the major hepatoprotective flavonolignan diastereomers from the fruits of Silybum marianum, with the culture broth of Trichoderma koningii gave two pairs of glucosylated derivatives. Their structures were identified as silybin A 3-O-beta-D-glucopyranoside (3), silybin A 7-O-beta-D-glucopyranoside (4), silybin B 3-O-beta-D-glucopyranoside (5) and silybin B 7-O-beta-D-glucopyranoside (6) by spectroscopic methods.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fruit / chemistry
  • Milk Thistle / chemistry
  • Molecular Conformation
  • Nuclear Magnetic Resonance, Biomolecular / methods
  • Silybin
  • Silymarin / chemistry
  • Silymarin / metabolism
  • Stereoisomerism
  • Structure-Activity Relationship
  • Trichoderma / metabolism*

Substances

  • Silymarin
  • Silybin