Obstructive sleep apnea syndrome: a potential cause of lower airway obstruction in cystic fibrosis

Sleep Med. 2006 Jan;7(1):73-5. doi: 10.1016/j.sleep.2005.07.002. Epub 2005 Nov 23.


A six-year-old healthy female with cystic fibrosis (CF) and pancreatic sufficiency presented with cough, weight loss, and lung function decline. Further history suggested obstructive sleep apnea, and nocturnal polysomnography (NPSG) confirmed this. Adenotonsillectomy resulted in resolution of clinical symptoms with return of normal lung function. This case establishes that obstructive sleep apnea syndrome (OSAS) may be a potential cause of lower airway inflammation and resulting weight loss in the young CF population.

Publication types

  • Case Reports

MeSH terms

  • Airway Obstruction / diagnosis
  • Airway Obstruction / etiology*
  • Airway Obstruction / metabolism
  • Bronchoscopy / methods
  • Carbon Dioxide / metabolism
  • Child
  • Cystic Fibrosis / complications*
  • Cystic Fibrosis / diagnosis
  • Female
  • Fiber Optic Technology / instrumentation
  • Humans
  • Polysomnography
  • Sleep Apnea Syndromes / etiology
  • Sleep Apnea Syndromes / metabolism
  • Sleep Apnea, Obstructive / diagnosis
  • Sleep Apnea, Obstructive / etiology*
  • Sleep Apnea, Obstructive / metabolism
  • Sleep, REM / physiology


  • Carbon Dioxide