The paradigm for study of anticipatory postural adjustments permits investigation of the coordination of postural and voluntary components of functional movement. The purpose of this study was to investigate whether there were anticipatory postural adjustments for voluntary movement in seated subjects under clinically relevant conditions. Eight neurologically normal subjects performed a reaching task to a target placed at shoulder height, 45 degrees to the right of midline. Onsets and magnitudes of lateral and fore-aft reactive forces associated with the movement and of electromyographic (EMG) activity of the ipsilateral deltoid and external abdominal oblique and contralateral paraspinal muscles were monitored. Conditions of trunk support, reach speed, and distance reached were manipulated. Onsets of deltoid muscle EMG activity preceded onsets of postural muscle (external oblique and paraspinal) EMG activity in 70% of all trials for seated subjects in contrast to reports of EMG activity onset in the postural muscles in advance of the prime mover in standing subjects who performed a similar task. The role of the trunk musculature and the significance of reactive forces in advance of hand movement were equivocal. This study has implications for evaluation of postural instability in persons unable to stand for testing.