This clinical report describes a treatment for the replacement of a missing mandibular anterior tooth using a cantilever single-retainer resin-bonded fixed partial denture (RBFPD), fabricated from zirconium dioxide (ZrO2) ceramic. No clinical complications were observed at the 2-year 6-month follow-up examination after placement of the ZrO2 ceramic RBFPD, and satisfactory functional and esthetic results were achieved. A treatment modality using a cantilever ZrO2 ceramic RBFPD is an alternative for single anterior tooth replacement. Further clinical studies are required to evaluate the long-term potential of cantilever single-retainer ZrO2 ceramic RBFPDs.