Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD)

Prostaglandins Leukot Essent Fatty Acids. 2006 Jan;74(1):17-21. doi: 10.1016/j.plefa.2005.10.001. Epub 2005 Nov 28.


Considerable clinical and experimental evidence now supports the idea that deficiencies or imbalances in certain highly unsaturated fatty acids may contribute to a range of common developmental disorders including Attention Deficit Hyperactivity Disorder (ADHD). Few intervention studies with LCPUFA supplementation have reported inconsistent and marginal results. This pilot study evaluates the effect of alpha linolenic acid (ALA)-rich nutritional supplementation in the form of flax oil and antioxidant emulsion on blood fatty acids composition and behavior in children with ADHD. Post-supplementation levels of RBC membrane fatty acids were significantly higher than pretreatment levels as well as the levels in control. There was significant improvement in the symptoms of ADHD reflected by reduction in total hyperactivity scores of ADHD children derived from ADHD rating scale.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ascorbic Acid / pharmacology
  • Ascorbic Acid / therapeutic use*
  • Attention Deficit Disorder with Hyperactivity / blood
  • Attention Deficit Disorder with Hyperactivity / diagnosis
  • Attention Deficit Disorder with Hyperactivity / drug therapy*
  • Child
  • Dietary Supplements*
  • Drug Therapy, Combination
  • Erythrocytes / chemistry
  • Erythrocytes / drug effects
  • Fatty Acids, Essential / pharmacology
  • Fatty Acids, Essential / therapeutic use
  • Fatty Acids, Unsaturated / blood
  • Female
  • Humans
  • Linseed Oil / pharmacology
  • Linseed Oil / therapeutic use*
  • Male
  • Pilot Projects
  • Thiobarbituric Acid Reactive Substances / analysis
  • Treatment Outcome
  • Vitamins / pharmacology
  • Vitamins / therapeutic use
  • alpha-Linolenic Acid / pharmacology
  • alpha-Linolenic Acid / therapeutic use


  • Fatty Acids, Essential
  • Fatty Acids, Unsaturated
  • Thiobarbituric Acid Reactive Substances
  • Vitamins
  • alpha-Linolenic Acid
  • Linseed Oil
  • Ascorbic Acid