Combined lung and liver transplantation: the United States experience

Transplantation. 2005 Nov 15;80(9):1161-7. doi: 10.1097/


Background: Combined transplantation of the lungs and liver is indicated for patients who would not be expected to survive transplantation of either organ alone. No single center has accumulated a significant experience, and as a result the expectations for this operation in the current era are unknown.

Methods: Patients that have undergone combined lung-liver transplantation in the United States were enrolled through the United Network for Organ Sharing Organ Procurement and Transplantation Network database. In addition, the English-language literature was searched for additional cases of combined lung-liver transplantation.

Results: Eleven patients have undergone combined lung and liver transplantation in the United States at different centers. The 1- and 5-year patient survival rates are of 79% and 63%, respectively, and no patient has required retransplantation. These patient survival rates are equivalent to similar a combined lung-liver case series from the United Kingdom (P=0.37, log-rank test) and isolated orthotopic liver transplantation in the United States (P=0.59, log-rank test), and are comparable to patient survival rates following isolated lung transplantation in the United States.

Conclusions: Patient survival of combined lung-liver transplantation is comparable to that of isolated liver and isolated bilateral lung transplantation. This option should be considered for patients with end-stage lung disease and liver disease when transplantation of a single organ transplantation is precluded by severe disease in the other organ system.

Publication types

  • Case Reports
  • Meta-Analysis
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Databases, Factual
  • Female
  • Humans
  • Liver Transplantation* / statistics & numerical data
  • Lung Transplantation* / statistics & numerical data
  • Male
  • Middle Aged
  • Survival Analysis
  • Tissue and Organ Procurement
  • United States