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Review
. 2005 Oct;6(10):777-88.
doi: 10.1038/nrm1739.

The Cell Biology of Neurogenesis

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Review

The Cell Biology of Neurogenesis

Magdalena Götz et al. Nat Rev Mol Cell Biol. .

Abstract

During the development of the mammalian central nervous system, neural stem cells and their derivative progenitor cells generate neurons by asymmetric and symmetric divisions. The proliferation versus differentiation of these cells and the type of division are closely linked to their epithelial characteristics, notably, their apical-basal polarity and cell-cycle length. Here, we discuss how these features change during development from neuroepithelial to radial glial cells, and how this transition affects cell fate and neurogenesis.

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