High resolution printing of DNA feature on poly(methyl methacrylate) substrates using supramolecular nano-stamping

J Am Chem Soc. 2005 Dec 7;127(48):16774-5. doi: 10.1021/ja055762e.


In recent years, a large number of devices based on organic and biological materials have been developed. To scale-up the production of these systems to industrially acceptable standards, there is a need to develop soft-material stamping approaches with the needed resolution, complexity, and versatility. We have recently developed a DNA-based stamping method (supramolecular nano-stamping, SuNS) that has superior resolution and can print multiple molecules at the same time. A similar technique was independently developed by Crooks and co-workers. Here we show that SuNS can be used to efficiently print DNA features on a polymeric substrate (poly(methyl methacrylate), PMMA) with a 40 nm point resolution and a coverage that exceeds 100 mum2. The stamped PMMA substrate was also used as a master to print on a gold substrate. With PMMA being optically clear and electrically insulating, future applications of SuNS to print DNA micro- and nanoarrays are envisioned.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA, Single-Stranded / chemistry*
  • Microscopy, Atomic Force
  • Nanotechnology / methods*
  • Polymethyl Methacrylate / chemistry*


  • DNA, Single-Stranded
  • Polymethyl Methacrylate