The effect of mass influenza immunization in children on the morbidity of the unvaccinated elderly

Epidemiol Infect. 2006 Feb;134(1):71-8. doi: 10.1017/S0950268805005650. Epub 2005 Nov 29.


The objectives of these studies were to analyse the effect of mass influenza immunization in children on the morbidity of unvaccinated non-institutionalized elderly during an influenza epidemic. A mass vaccination campaign with vaccine was conducted in children aged 3-6 years attending kindergartens (57.4% of 6374) and aged 7-17 years attending schools (72% of 34237) in two communities of the Moscow region. The clinical effectiveness of vaccination was 60.9% for kindergartens and 68.8% for schools. There were 3.4 times fewer episodes of influenza-like illnesses and 1.7-2.6 fewer episodes in all seven diseases which are possible complications of influenza out of the 10 evaluated diseases in 158451 unvaccinated non-institutionalized elderly people during the influenza epidemic compared with the control communities. The differences were found to be statistically significant. Mass vaccination of children attending child institutions brought about a significant reduction of both influenza-like illnesses in children and influenza-associated illnesses in unvaccinated non-institutionalized elderly persons living in the home setting.

MeSH terms

  • Aged
  • Child
  • Child Care
  • Child, Preschool
  • Disease Outbreaks*
  • Humans
  • Immunization Programs
  • Influenza Vaccines / therapeutic use*
  • Influenza, Human / complications*
  • Influenza, Human / epidemiology*
  • Middle Aged
  • Morbidity
  • Moscow / epidemiology
  • Residence Characteristics
  • Risk Factors


  • Influenza Vaccines