[The role of CD25 antibody in unrelated hematopoietic stem cell transplantation]

Zhonghua Nei Ke Za Zhi. 2005 Nov;44(11):848-50.
[Article in Chinese]


Objective: To explore the role of CD(25) antibody on engraftment and graft-versus-host disease (GVHD) prophylaxis in unrelated hematopoietic stem cell transplantation (UHSCT).

Methods: CD(25) 1 mg/kg was given on day 1, day 4 post-transplantation in 27 patients of UHSCT.

Results: Hematopoietic recovery was obtained in 26 patients. One patient died before hematopoietic recovery. Acute GVHD occurred in 17 patients and 6 patients with II or more than degree acute GVHD (23%). Three patients experienced relapse and other 3 patients with serious infection. In these 26 eligible patients, 19 patients got disease free survival.

Conclusions: CD(25) antibody plays an important role on engraftment and GVHD prophylaxis in the treatment of UHSCT and does not increase rate of leukemia relapse. It provides a way of GVHD prophylaxis in unrelated and HLA mismatched hematopoietic stem cell transplantation.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Monoclonal / therapeutic use*
  • Child
  • Female
  • Graft vs Host Disease / etiology
  • Graft vs Host Disease / prevention & control*
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Leukemia / therapy*
  • Male
  • Middle Aged
  • Receptors, Interleukin-2 / immunology*


  • Antibodies, Monoclonal
  • Immunosuppressive Agents
  • Receptors, Interleukin-2