In silico patent searching reveals a new cannabinoid receptor

Trends Pharmacol Sci. 2006 Jan;27(1):1-4. doi: 10.1016/ Epub 2005 Nov 28.


Increasing evidence suggests that some cannabinoids mediate their effects independently of the known cannabinoid CB(1) and CB(2) receptors. Two recently published patents indicate that several cannabinoid receptor ligands also bind to the orphan G-protein-coupled receptor GPR55. This receptor is reported to be expressed in several tissues and might function in lipid or vascular biology. Thus, GPR55 might represent a new cannabinoid receptor.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Molecular Sequence Data
  • Patents as Topic
  • Receptors, Cannabinoid / analysis
  • Receptors, Cannabinoid / chemistry
  • Receptors, Cannabinoid / physiology*
  • Receptors, G-Protein-Coupled / analysis
  • Receptors, G-Protein-Coupled / chemistry
  • Receptors, G-Protein-Coupled / physiology*


  • Receptors, Cannabinoid
  • Receptors, G-Protein-Coupled