Alpha-adrenergic blockers on ventricular automatism in rat heart

Rev Esp Fisiol. 1977 Mar;33(1):63-6.


The role of the alpha-adrenergic receptors in the genesis of cardiac arrhythmias induced in the isolated rat right ventricle has been studied. The administration of six alpha-adrenergic blocking agents (phenoxybenzamine, dibenamine, phentolamine, tolazoline, azapetine and SY-28) did not alter the automatism induced. Even when can not be excluded the existance of alpha-adrenergic receptors in the rat ventricle, it is clear that alpha-blocking drugs are ineffective to abolish the arrhythmias induced by an increase in the activity of the Purkinje fibers.

Publication types

  • Comparative Study

MeSH terms

  • Adrenergic beta-Antagonists / pharmacology*
  • Animals
  • Anti-Arrhythmia Agents
  • Female
  • Heart Conduction System / physiology*
  • Heart Rate / drug effects
  • Male
  • Myocardial Contraction / drug effects
  • Purkinje Fibers / physiology*
  • Rats
  • Receptors, Adrenergic, alpha / drug effects
  • Stimulation, Chemical
  • Ventricular Function*


  • Adrenergic beta-Antagonists
  • Anti-Arrhythmia Agents
  • Receptors, Adrenergic, alpha