Hormone replacement therapy and longitudinal cognitive performance in postmenopausal women

Am J Geriatr Psychiatry. 2005 Dec;13(12):1107-10. doi: 10.1176/appi.ajgp.13.12.1107.


Objective: The authors examined the impact of hormone replacement therapy (HRT) on longitudinal cognitive performance (controlling for mood state) in 69 community-dwelling, postmenopausal women.

Methods: The authors conducted a 5-year follow-up of cognitive performance in 37 postmenopausal HRT users and 32 non-users. The groups did not differ with respect to age, years of education, or inter-test interval.

Results: No main effect of HRT was observed on any of the cognitive measures, and depressive symptomatology did not affect the relationship between HRT and cognition.

Conclusion: Overall, our findings do not suggest that HRT affects longitudinal cognitive performance in postmenopausal, community-dwelling older women.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cognition / drug effects*
  • Cross-Sectional Studies
  • Female
  • Follow-Up Studies
  • Hormone Replacement Therapy / methods*
  • Humans
  • Middle Aged
  • Neuropsychological Tests
  • Postmenopause / physiology*
  • Surveys and Questionnaires