Risk factors regarding the need for a second operation in patients with Crohn's disease

Digestion. 2005;72(4):248-53. doi: 10.1159/000089960. Epub 2005 Nov 25.


Background/aims: The majority of Crohn's disease patients undergo surgery. However, the factors that predict post-operative recurrence remain controversial. The aim of the present study was to shed light on the potential predictors of such recurrence.

Methods: 86 patients who underwent operative procedures for Crohn's disease were retrospectively studied. Recurrence was defined as the need for a second operation. Life table and multivariate analysis were performed to find the predictors of recurrence.

Results: In 26/86 (30%) of the patients, post-operative recurrence was diagnosed within a mean of 42 months of the follow-up. Logistic regression analysis revealed that smoking (OR 3.69, 95% CI 2.06-11.52) and perforating disease (OR 4.09, 95% CI 1.31-12.65) were associated with a risk of recurrence. However, survival analysis showed that only perforating disease was associated with an early post-operative recurrence (log-rank test, p < 0.001). Neither resected surgical specimen characteristics, nor the duration and the location of the disease were found to predict the need for a second operation.

Conclusion: The risk for Crohn's disease patients who undergo surgery is related to the presence of perforating disease and smoking, which predict the need for a second operation. The former is associated with an even earlier recurrence.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Crohn Disease / surgery*
  • Digestive System Surgical Procedures*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Postoperative Period
  • Prognosis
  • Recurrence
  • Referral and Consultation*
  • Regression Analysis
  • Reoperation
  • Retrospective Studies
  • Risk Factors
  • Smoking / adverse effects