Temporal regulation in the early embryo: is MBT too good to be true?

Trends Genet. 1992 Apr;8(4):124-7. doi: 10.1016/0168-9525(92)90369-F.


The question of how early embryonic events are temporally regulated has traditionally been tied to the mid-blastula transition (MBT). This concept has directed the studies in Xenopus and influenced the studies in other organisms. By examining the weaknesses in the concept of MBT, we hope to refocus the study of temporal regulation on the many developmental transitions that do exist and to clear the way for an alternative viewpoint that emphasizes the similarities between developmental processes in different organisms.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Blastocyst / physiology*
  • Cell Cycle / physiology
  • Drosophila
  • Embryonic Induction / physiology*
  • Gastrula / physiology
  • Sea Urchins
  • Transcription, Genetic / physiology
  • Xenopus