Membrane curvature and mechanisms of dynamic cell membrane remodelling

Nature. 2005 Dec 1;438(7068):590-6. doi: 10.1038/nature04396.


Membrane curvature is no longer seen as a passive consequence of cellular activity but an active means to create membrane domains and to organize centres for membrane trafficking. Curvature can be dynamically modulated by changes in lipid composition, the oligomerization of curvature scaffolding proteins and the reversible insertion of protein regions that act like wedges in membranes. There is an interplay between curvature-generating and curvature-sensing proteins during vesicle budding. This is seen during vesicle budding and in the formation of microenvironments. On a larger scale, membrane curvature is a prime player in growth, division and movement.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Membrane / chemistry*
  • Cell Membrane / metabolism*
  • Cytoskeleton / metabolism
  • Membrane Lipids / metabolism
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism
  • Microtubules / metabolism
  • Molecular Motor Proteins / metabolism


  • Membrane Lipids
  • Membrane Proteins
  • Molecular Motor Proteins