Effects of topical sesame oil on oxidative stress in rats

Altern Ther Health Med. 2005 Nov-Dec;11(6):40-5.


Objective: To assess the effects of topical sesame oil on systemic oxidative stress in rats.

Design: Oxidative stress was induced with lipopolysaccharide and assessed by determining serum lipid peroxidation, superoxide anion, and hydroxyl radical levels. The levels of 3 circulating antioxidants--superoxide dismutase, catalase, and glutathione--also were determined.

Results: Topical sesame oil significantly reduced lipid peroxidation, superoxide anion, and hydroxyl radical levels after lipopolysaccharide administration. However, sesame oil did not affect the 3 circulating antioxidants. Further, sesame oil decreased the activity of xanthine oxidase and nitric oxide production in lipopolysaccharide-treated rats.

Conclusion: Sesame oil given topically might attenuate oxidative stress by inhibiting the production of xanthine oxidase and nitric oxide in rats.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Catalase / analysis
  • Catalase / drug effects
  • Disease Models, Animal
  • Glutathione / analysis
  • Glutathione / drug effects
  • Lipid Peroxidation / drug effects*
  • Lipopolysaccharides
  • Luminescent Measurements
  • Male
  • Oxidative Stress / drug effects*
  • Probability
  • Rats
  • Rats, Wistar
  • Reactive Oxygen Species / analysis*
  • Reactive Oxygen Species / metabolism
  • Sensitivity and Specificity
  • Sesame Oil / administration & dosage
  • Sesame Oil / pharmacology*
  • Superoxide Dismutase / analysis
  • Superoxide Dismutase / drug effects


  • Lipopolysaccharides
  • Reactive Oxygen Species
  • Sesame Oil
  • Catalase
  • Superoxide Dismutase
  • Glutathione