Abstract
[chemical structure: see text]. Two natural products have been synthesized using a ZnCl2-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents* / chemical synthesis
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Anti-Bacterial Agents* / chemistry
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Anti-Bacterial Agents* / pharmacology
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Bacterial Proteins / drug effects*
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Bacterial Proteins / physiology
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Biological Products* / chemical synthesis
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Biological Products* / chemistry
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Biological Products* / pharmacology
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Chlorides
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Cytokinesis / physiology
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Cytoskeletal Proteins / drug effects*
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Cytoskeletal Proteins / physiology
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Enzyme Inhibitors* / chemical synthesis
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Enzyme Inhibitors* / chemistry
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Enzyme Inhibitors* / pharmacology
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Flavanones* / chemical synthesis
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Flavanones* / chemistry
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Flavanones* / pharmacology
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GTP Phosphohydrolases / antagonists & inhibitors*
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Stereoisomerism
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Zinc Compounds
Substances
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2'''-hydroxy-5''-benzylisouvarinol-B
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Anti-Bacterial Agents
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Bacterial Proteins
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Biological Products
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Chlorides
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Cytoskeletal Proteins
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Enzyme Inhibitors
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Flavanones
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FtsZ protein, Bacteria
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Zinc Compounds
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dichamanetin
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zinc chloride
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GTP Phosphohydrolases