The L-type calcium channel in the heart: the beat goes on

J Clin Invest. 2005 Dec;115(12):3306-17. doi: 10.1172/JCI27167.


Sydney Ringer would be overwhelmed today by the implications of his simple experiment performed over 120 years ago showing that the heart would not beat in the absence of Ca2+. Fascination with the role of Ca2+ has proliferated into all aspects of our understanding of normal cardiac function and the progression of heart disease, including induction of cardiac hypertrophy, heart failure, and sudden death. This review examines the role of Ca2+ and the L-type voltage-dependent Ca2+ channels in cardiac disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Amino Acid Motifs
  • Animals
  • Atrial Fibrillation
  • Calcium / metabolism
  • Calcium Channels, L-Type / physiology*
  • Calmodulin / chemistry
  • Calmodulin / metabolism
  • Heart Failure / metabolism
  • Humans
  • Models, Biological
  • Myocytes, Cardiac / cytology
  • Protein Isoforms
  • Protein Structure, Tertiary
  • Tissue Distribution


  • Calcium Channels, L-Type
  • Calmodulin
  • Protein Isoforms
  • Calcium