Platelets in Inflammation and Atherogenesis

J Clin Invest. 2005 Dec;115(12):3378-84. doi: 10.1172/JCI27196.

Abstract

Platelets represent an important linkage between inflammation, thrombosis, and atherogenesis. Inflammation is characterized by interactions among platelets, leukocytes, and ECs. These interactions trigger autocrine and paracrine activation processes that lead to leukocyte recruitment into the vascular wall. Platelet-induced chronic inflammatory processes at the vascular wall result in development of atherosclerotic lesions and atherothrombosis. This Review highlights the molecular machinery and inflammatory pathways used by platelets to initiate and accelerate atherothrombosis.

Publication types

  • Review

MeSH terms

  • Animals
  • Arteriosclerosis / pathology
  • Atherosclerosis / pathology*
  • Blood Platelets / metabolism
  • Blood Platelets / pathology
  • Blood Platelets / physiology*
  • Cell Adhesion
  • Disease Models, Animal
  • Hemostasis
  • Humans
  • Inflammation*
  • Models, Biological
  • Monocytes / cytology
  • Platelet Adhesiveness
  • Selectins / metabolism
  • Thrombosis / pathology

Substances

  • Selectins