New ways in which GLP-1 can regulate glucose homeostasis

J Clin Invest. 2005 Dec;115(12):3406-8. doi: 10.1172/JCI27207.


Glucagon-like peptide-1 (GLP-1) has a diverse set of peripheral actions which all serve to promote enhanced glucose tolerance, and for this reason it has become the basis for new treatments for type 2 diabetes. In this issue of the JCI, Knauf et al. provide clear evidence that GLP-1 signaling in the CNS is also linked to the control of peripheral glucose homeostasis by inhibiting non-insulin-mediated glucose uptake by muscle and increasing insulin secretion from the pancreas. The authors' work points to an important need to integrate diverse GLP-1 signaling actions and peripheral GLP-1 function in order to better understand both normal and abnormal glucose homeostasis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Brain / metabolism
  • Central Nervous System / metabolism
  • Diabetes Mellitus, Type 2 / metabolism
  • Glucagon / metabolism
  • Glucagon-Like Peptide 1 / metabolism
  • Glucagon-Like Peptide 1 / physiology*
  • Glucose / metabolism*
  • Homeostasis*
  • Humans
  • Insulin / metabolism
  • Models, Biological
  • Peptide Fragments / chemistry
  • Proglucagon / metabolism


  • Insulin
  • Peptide Fragments
  • Proglucagon
  • Glucagon-Like Peptide 1
  • Glucagon
  • Glucose