Identification of oxidatively modified lipids in atherosclerotic lesions of human aortas

J Belkner; R Wiesner; H Kühn

doi:10.1007/978-3-0348-7262-1_12

Identification of oxidatively modified lipids in atherosclerotic lesions of human aortas

Agents Actions Suppl. 1992:37:78-84. doi: 10.1007/978-3-0348-7262-1_12.

Authors

J Belkner¹, R Wiesner, H Kühn

Affiliation

¹ Institute of Biochemistry, Medical School, Charité, Humboldt Universitity Berlin, Germany.

PMID: 1632313
DOI: 10.1007/978-3-0348-7262-1_12

Abstract

The oxygenated lipids of human aortas with atherosclerotic lesions were analysed by RP-, SP- and Chiral Phase-HPLC and compared with those obtained after treatment of human LDL with pure 15-lipoxygenase (LOX) of rabbit reticulocytes. The data suggest an indirect role of 15-LOX in the atherogenesis in aortas.

MeSH terms

Aged
Aged, 80 and over
Animals
Aorta, Abdominal / metabolism*
Arteriosclerosis / metabolism*
Cholesterol / blood
Chromatography, High Pressure Liquid
Humans
In Vitro Techniques
Lipid Metabolism*
Lipoproteins, LDL / blood
Lipoxygenase / pharmacology
Male
Middle Aged
Oxidation-Reduction
Rabbits
Reticulocytes / metabolism
Spectrophotometry, Ultraviolet

Substances

Lipoproteins, LDL
Cholesterol
Lipoxygenase