The battlefield of pluripotency

Cell. 2005 Dec 2;123(5):757-60. doi: 10.1016/j.cell.2005.11.012.

Abstract

How embryonic stem cells maintain the potential to differentiate into multiple cell lineages is still unclear. In this issue of Cell, Niwa et al. (2005) show that a duel between the transcription factors Oct3/4 and Cdx2 can restrict embryonic stem cells to either embryonic or placental fate. The vulnerability of lineage potential to transcriptional perturbation may reflect an essential feature of pluripotency.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Blastocyst / cytology
  • Blastocyst / metabolism
  • CDX2 Transcription Factor
  • Cell Differentiation / physiology
  • Cell Lineage*
  • Homeodomain Proteins / metabolism
  • Mice
  • Octamer Transcription Factor-3 / metabolism
  • Organic Cation Transport Proteins / metabolism
  • Pluripotent Stem Cells / cytology
  • Pluripotent Stem Cells / physiology*
  • Transcription Factors / metabolism

Substances

  • CDX2 Transcription Factor
  • Cdx2 protein, mouse
  • Homeodomain Proteins
  • Octamer Transcription Factor-3
  • Organic Cation Transport Proteins
  • Pou5f1 protein, mouse
  • Transcription Factors
  • solute carrier family 22 (organic cation transporter), member 3