Can 1000 reviews be wrong? Actin, alpha-Catenin, and adherens junctions

Cell. 2005 Dec 2;123(5):769-72. doi: 10.1016/j.cell.2005.11.009.

Abstract

Coupling between cell adhesion and the actin cytoskeleton is thought to require a stable link between the cadherin-catenin complex and actin that is mediated by alpha-catenin. In this issue of Cell, the Weis and Nelson groups call this static model into question, showing that alpha-catenin can directly regulate actin dynamics (Drees et al., 2005 and Yamada et al., 2005).

Publication types

  • Comment
  • Review

MeSH terms

  • Actins / metabolism*
  • Adherens Junctions / metabolism*
  • Animals
  • Cell Adhesion / physiology
  • Models, Biological*
  • Multiprotein Complexes
  • alpha Catenin / metabolism*

Substances

  • Actins
  • Multiprotein Complexes
  • alpha Catenin