An intervention study of smoking cessation with feedback on genetic cancer susceptibility in Japan

Prev Med. 2006 Feb;42(2):102-8. doi: 10.1016/j.ypmed.2005.10.006. Epub 2005 Dec 2.


Background: To evaluate whether feedback of genetic information regarding an L-myc polymorphism, identified as impacting on tobacco-related cancer risk, has an influence on smoking cessation, an intervention study was conducted.

Methods: We recruited smokers from first-visit outpatients at Aichi Cancer Center Hospital. Six hundred and seventeen participated and were allocated into two groups: the biomarker feedback group (BF) and the follow-up smoking status group (FS). The subjects were asked for their smoking status at enrolment and at 3- and 9-month follow-ups. BF subjects were notified about their L-myc genotype.

Results: The smoking cessation rate at 9-month follow-up was essentially the same for both BF and FS cases, at 18.8% and 17.0%, respectively (P = 0.798). However, a difference in the rate was evident with non-cancer subjects (12.7% and 8.4%, respectively, P = 0.237), especially in females (15.0% and 4.2%, respectively, P = 0.024). The non-cancer subjects informed of their genotype were more likely to quit smoking than the FS patients; particularly in those having a risky genotype, this was significant (odds ratio: 2.87, P = 0.003). Again it was most prominent in females.

Conclusion: Feedback regarding an L-myc polymorphism did not impact on smoking cessation overall but appeared to benefit smokers without cancer. In addition, gender could affect the response to the feedback.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Female
  • Genes, myc
  • Genetic Markers
  • Genetic Predisposition to Disease / genetics
  • Genetic Predisposition to Disease / psychology*
  • Genetic Testing*
  • Humans
  • Japan
  • Knowledge of Results, Psychological*
  • Male
  • Middle Aged
  • Motivation*
  • Neoplasms / genetics*
  • Neoplasms / prevention & control
  • Neoplasms / psychology
  • Polymorphism, Genetic
  • Smoking Cessation*


  • Genetic Markers