Herpesvirus Interference With Virus-Specific Antibodies: Bridging Antibodies, Internalizing Antibodies, and Hiding From Antibodies

Vet Microbiol. 2006 Mar 31;113(3-4):257-63. doi: 10.1016/j.vetmic.2005.11.003. Epub 2005 Dec 2.


Herpesviruses have developed different tools to thwart efficient antibody-dependent neutralisation and lysis of virions and elimination of infected cells. This overview will briefly summarize different of these tools, including (i) viral Fc receptors and the resulting process of antibody bridging, (ii) internalization of individual viral proteins and clustered antibody-antigen complexes from the plasma membrane of infected cells, and (iii) directed egress of virus particles to sites of intimate cell-cell contact that are difficult to access for antibodies.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Viral / immunology*
  • Antigen-Antibody Complex / immunology
  • Antigens, Viral / immunology
  • Cell Communication / immunology
  • Cytotoxicity Tests, Immunologic
  • Herpesviridae / immunology*
  • Membrane Glycoproteins / immunology
  • Receptors, Fc / immunology
  • Viral Envelope Proteins / immunology*


  • Antibodies, Viral
  • Antigen-Antibody Complex
  • Antigens, Viral
  • Membrane Glycoproteins
  • Receptors, Fc
  • Viral Envelope Proteins