Influence of acute vitamin C and/or carbohydrate ingestion on hormonal, cytokine, and immune responses to prolonged exercise

Int J Sport Nutr Exerc Metab. 2005 Oct;15(5):465-79. doi: 10.1123/ijsnem.15.5.465.

Abstract

The aim of the present study was to investigate the effect of vitamin C with or without carbohydrate consumed acutely in beverages before and during prolonged cycling on immunoendocrine responses. In a single blind, randomized manner six healthy, moderately trained males exercised for 2.5 h at 60% VO(2max)and consumed either placebo (PLA), carbohydrate (CHO, 6% w/v), vitamin C (VC, 0.15% w/v) or CHO+VC beverages before and during the bouts; trials were separated by 1 wk. CHO and CHO+VC significantly blunted the post-exercise increase in plasma concentrations of cortisol, ACTH, total leukocyte, and neutrophil counts and limited the decrease in plasma glucose concentration and bacteria-stimulated neutrophil degranulation. VC increased plasma antioxidant capacity (PAC) during exercise (P < 0.05) but had no effect on any of the immunoendocrine responses (P > 0.05). CHO+VC increased PAC compared to CHO but had no greater effects,p above those observed with CHO alone, on any of the immunoendocrine responses. In conclusion, acute supplementation with a high dose of VC has little or no effect on the hormonal, interleukin-6, or immune response to prolonged exercise and combined ingestion of VC with CHO provides no additional effects compared with CHO alone.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adrenocorticotropic Hormone / blood
  • Adult
  • Antioxidants / administration & dosage*
  • Ascorbic Acid / administration & dosage*
  • Beverages
  • Bicycling / physiology
  • Cross-Over Studies
  • Dietary Carbohydrates / administration & dosage*
  • Exercise / physiology*
  • Humans
  • Hydrocortisone / blood
  • Leukocyte Count
  • Male
  • Neutrophils / immunology
  • Neutrophils / metabolism
  • Oxygen Consumption* / drug effects
  • Oxygen Consumption* / immunology
  • Oxygen Consumption* / physiology
  • Single-Blind Method

Substances

  • Antioxidants
  • Dietary Carbohydrates
  • Adrenocorticotropic Hormone
  • Ascorbic Acid
  • Hydrocortisone