Immune reconstitution inflammatory syndrome in HIV-infected patients with disseminated histoplasmosis

AIDS. 2006 Jan 2;20(1):119-21. doi: 10.1097/01.aids.0000199014.66139.39.


Four HIV-1-infected patients presented with unusual clinical manifestations in the course of disseminated histoplasmosis, including liver abscesses, compressive lymphadenitis, intestinal obstruction, uveitis and arthritis within a median of 45 days after initiation of highly active antiretroviral therapy (HAART). They had a median increase of 106 CD4 cells/mul and granulomas with caseation in three. Partial immune reconstitution induced by HAART during disseminated histoplasmosis either related to the variety capsulatum or duboisii may be associated with immune reconstitution inflammatory syndrome.

Publication types

  • Case Reports

MeSH terms

  • AIDS-Related Opportunistic Infections / immunology
  • Adult
  • Antifungal Agents / therapeutic use
  • Antiretroviral Therapy, Highly Active / adverse effects
  • Female
  • HIV Infections / drug therapy
  • HIV Infections / immunology*
  • Histoplasmosis / immunology*
  • Humans
  • Immunity, Cellular
  • Itraconazole / therapeutic use
  • Male
  • Middle Aged
  • Syndrome
  • Treatment Outcome


  • Antifungal Agents
  • Itraconazole