Radiation and the microenvironment - tumorigenesis and therapy

Nat Rev Cancer. 2005 Nov;5(11):867-75. doi: 10.1038/nrc1735.


Radiation rapidly and persistently alters the soluble and insoluble components of the tissue microenvironment. This affects the cell phenotype, tissue composition and the physical interactions and signalling between cells. These alterations in the microenvironment can contribute to carcinogenesis and alter the tissue response to anticancer therapy. Examples of these responses and their implications are discussed with a view to therapeutic intervention.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / radiation effects*
  • Cells / radiation effects*
  • Humans
  • Neoplasms / etiology*
  • Neoplasms / radiotherapy*
  • Neoplasms, Radiation-Induced*
  • Radiation, Ionizing*