Growth inhibition of leukemia cell line CEM-C1 by farnesol: effects of phosphatidylcholine and diacylglycerol

Biochem Biophys Res Commun. 1992 Jul 15;186(1):543-8. doi: 10.1016/s0006-291x(05)80842-3.


Acute leukemia cells of the established line CEM-C1 were treated during growth in serum-free medium with various concentrations of trans-trans farnesol. At concentrations ranging from 9.0 to 31.5 microM, farnesol inhibited growth of these cells without causing cell lysis. This effect was preceded by very rapid inhibition of choline incorporation in cellular lipid fraction. The growth inhibitory effect was prevented to a large extent by incubation with phosphatidylcholine or diacylglycerol.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acyclic Monoterpenes
  • Cell Division / drug effects*
  • Cell Line
  • Diglycerides / pharmacology*
  • Dolichols / pharmacology
  • Dose-Response Relationship, Drug
  • Farnesol / pharmacology*
  • Humans
  • Isomerism
  • Kinetics
  • Leukemia-Lymphoma, Adult T-Cell
  • Phosphatidylcholines / pharmacology*
  • Squalene / pharmacology
  • Terpenes / pharmacology


  • Acyclic Monoterpenes
  • Diglycerides
  • Dolichols
  • Phosphatidylcholines
  • Terpenes
  • Farnesol
  • Squalene
  • geraniol
  • diolein