Oral administration of beta-cryptoxanthin prevents bone loss in ovariectomized rats

Int J Mol Med. 2006 Jan;17(1):15-20.

Abstract

The effect of beta-cryptoxanthin, a kind of carotenoid, on ovariectomy-induced bone loss was investigated. beta-cryptoxanthin was isolated from Satsuma mandarin (Citrus unshu. MARC). beta-cryptoxanthin (5 or 10 microg/100 g body weight) was orally administered once daily for 3 months to ovariectomized (OVX) rats. OVX induced a significant increase in body weight and a significant decrease in serum calcium and inorganic phosphorus concentrations as compared with those of sham-operated (control) rats. These alterations induced by OVX were significantly prevented by the administration of beta-cryptoxanthin (5 or 10 microg/100 g). The analysis using a peripheral quantitative computed tomography (pQCT) showed that OVX induced a significant decrease in mineral content and mineral density in the femoral-diaphyseal and -metaphyseal tissues and polar strength strain index in the metaphyseal tissues. These decreases were significantly prevented by the administration of beta-cryptoxanthin (5 or 10 microg/100 g). Moreover, OVX induced a significant decrease in calcium content and alkaline phosphatase activity in the femoral-diaphyseal and -metaphyseal tissues and deoxyribonucleic acid (DNA) content in the metaphyseal tissues. These decreases were significantly prevented by the administration of beta-cryptoxanthin (5 or 10 microg/100 g). This study demonstrates that beta-cryptoxanthin has a preventive effect on OVX-induced bone loss in vivo.

MeSH terms

  • Administration, Oral
  • Animals
  • Anticarcinogenic Agents / pharmacology*
  • Body Weight
  • Bone Density / drug effects*
  • Bone Resorption / prevention & control*
  • Cryptoxanthins
  • Female
  • Femur / anatomy & histology
  • Femur / drug effects
  • Femur / pathology
  • Humans
  • Osteoporosis, Postmenopausal / prevention & control
  • Ovariectomy*
  • Rats
  • Rats, Wistar
  • Xanthophylls
  • beta Carotene / analogs & derivatives*
  • beta Carotene / pharmacology

Substances

  • Anticarcinogenic Agents
  • Cryptoxanthins
  • Xanthophylls
  • beta Carotene