Synchronous bilateral ductal carcinoma in situ of the male breast associated with gynecomastia in a 30-year-old patient following repeated injections of stanozolol

Breast Cancer Res Treat. 2006 May;97(2):173-6. doi: 10.1007/s10549-005-9107-6. Epub 2005 Dec 3.


We report a rare case of synchronous bilateral and multifocal ductal carcinoma in situ (DCIS) in a 30-year-old patient operated on for gynecomastia following repeated injections of stanozolol, a non-aromatizable androgen. The familial medical history was negative for breast cancer and work-up of serum hormone levels was normal. The patient underwent a modified radical mastectomy without axilla dissection 6 weeks following the primary procedure and recovered uneventfully. The role of synthetic androgens in the development of male breast neoplasia warrants further scrutiny.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Androgens / administration & dosage
  • Androgens / adverse effects*
  • Axilla
  • Breast Neoplasms, Male / etiology*
  • Breast Neoplasms, Male / surgery
  • Carcinoma, Intraductal, Noninfiltrating / etiology*
  • Carcinoma, Intraductal, Noninfiltrating / surgery
  • Gynecomastia / complications*
  • Gynecomastia / drug therapy
  • Gynecomastia / pathology
  • Gynecomastia / surgery
  • Humans
  • Male
  • Mastectomy
  • Stanozolol / administration & dosage
  • Stanozolol / adverse effects*


  • Androgens
  • Stanozolol