Effects of obesity and race on prognosis in lymph node-negative, estrogen receptor-negative breast cancer

Breast Cancer Res Treat. 2006 Jun;97(3):245-54. doi: 10.1007/s10549-005-9118-3. Epub 2005 Dec 6.


Background: Several factors may contribute to poorer prognosis for obese breast cancer patients, including unfavorable disease features, the influence of fat on estrogen availability, co-morbidity, and socio-demographic factors. Both obesity and estrogen receptor negative (ER-) tumors are more prevalent in black women than in whites in North America. We evaluated obesity and race in relation to outcomes in women with ER-breast cancer.

Methods: Among 4,077 women from National Surgical Adjuvant Breast and Bowel Project clinical trials for node-negative, ER-breast cancer, we evaluated disease-free survival (DFS) and its constituents (tumor recurrence, contralateral breast cancer (CBC), second primary cancers, deaths prior to these events) and mortality in relation to body mass index (BMI) and race, using statistical modeling to account for other prognostic factors.

Results: Compared to those of normal weight (BMI< or =24.9), DFS hazard was greater for obese (BMI > or = 30) women [hazard ratio (HR)=1.16, 95% confidence interval (CI)=1.01-1.33]. Obesity did not increase recurrence hazard, but did influence CBC (HR=2.08, 95% CI=1.22-3.55 in postmenopausal women) and second cancers (HR=1.49, 95% CI=1.06-2.10). Mortality increased with obesity; when partitioned by likely cause, those with BMI > or = 35.0 had greater risk of non-breast cancer mortality (HR=1.86, 95% CI=1.21-2.84). Relative to whites and adjusted for BMI, black women had greater hazard for DFS (HR=1.17, 95% CI=1.00-1.38), CBC (HR=1.37, 95% CI=0.94-1.99), and non-breast cancer deaths (HR=2.10, 95% CI=1.45-3.03); risk for deaths likely due to breast cancer was closer to that in whites (HR=1.18; 95% CI=0.93-1.50).

Conclusions: For women with node-negative, ER-breast cancer from clinical trials, obesity did not increase recurrence risk, but was associated with greater risk for second cancers, CBC, and mortality, particularly non-breast cancer deaths. Less favorable prognosis for black women persists in clinical trials, and is in part attributable to non-breast cancer outcomes.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • African Americans / statistics & numerical data*
  • Antineoplastic Agents / therapeutic use
  • Body Mass Index
  • Breast Neoplasms / complications*
  • Breast Neoplasms / ethnology*
  • Breast Neoplasms / mortality
  • Disease-Free Survival
  • European Continental Ancestry Group / statistics & numerical data*
  • Female
  • Humans
  • Lymph Nodes / pathology
  • Middle Aged
  • Multicenter Studies as Topic
  • North America / epidemiology
  • Obesity / complications*
  • Odds Ratio
  • Prognosis
  • Proportional Hazards Models
  • Randomized Controlled Trials as Topic
  • Receptors, Estrogen / analysis
  • Retrospective Studies
  • Survival Analysis


  • Antineoplastic Agents
  • Receptors, Estrogen