Mitotic spindle: disturbing a subtle balance

Curr Biol. 2005 Dec 6;15(23):R956-9. doi: 10.1016/j.cub.2005.11.015.

Abstract

Mitotic spindles maintain a roughly constant length in metaphase, so the forces between the spindle poles are balanced. A new study involving screening molecules believed to mediate this force balance has found that spindle length is relatively insensitive to perturbations of molecular motor force-generating activities, but more sensitive to perturbation of microtubule assembly regulators and chromosome cohesion.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomechanical Phenomena
  • Chromatids / physiology*
  • Metaphase / physiology*
  • Microtubule-Associated Proteins / physiology*
  • Models, Biological*
  • Molecular Motor Proteins / physiology*
  • Spindle Apparatus / physiology*

Substances

  • Microtubule-Associated Proteins
  • Molecular Motor Proteins