Blood group MN antigens and precursors in normal and malignant human breast glandular tissue

J Natl Cancer Inst. 1975 Feb;54(2):335-9.

Abstract

Blood group M and N active substances were demonstrated in human mammary gland tissue in both benign and malignant lesions. The precursor T (Thomsen-Friedenreich) antigen occurred only in cancerous tissue, where it was found regularly in the 15 gross cancers tested. The precursor Tn antigen also was found regularly in cancerous breast tissue; Both antigens were reactive in breasts with in situ carcinoma. The T antigen was not demonstrable in the 6 benign mammary glands studied; similarly, the Tn antigen was unmasked by sialidase treatment of healthy breast tissues. Anti-T antibody, present in all human sera, was severely depressed in many breast cancer patients compared to controls.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma / immunology*
  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents / analysis
  • Antigens, Neoplasm / analysis*
  • Blood Group Antigens*
  • Breast / immunology
  • Breast Neoplasms / immunology*
  • Carcinoma, Intraductal, Noninfiltrating / immunology*
  • Cell Membrane / immunology
  • Cytoplasm / immunology
  • Female
  • Humans
  • Isoantigens / analysis*
  • Neuraminidase / pharmacology

Substances

  • Anti-Bacterial Agents
  • Antigens, Neoplasm
  • Blood Group Antigens
  • Isoantigens
  • Neuraminidase