Glutathione S-transferase M1 gene null genotype and gastric cancer risk in Taiwan

Hepatogastroenterology. Nov-Dec 2005;52(66):1916-9.

Abstract

Background/aims: Glutathione S-transferases (GST) are involved in the detoxification of many potential carcinogens and appear to play an important role in the protection from carcinogens. The association between different GSTM1 genotypes and gastric cancer risk is still controversial. The aim of this study was to determine the association between the GSTM1-null genotype and gastric cancer risk.

Methodology: A retrospective, hospital-based case-control study of 123 primary gastric cancer patients and 121 healthy controls was conducted to evaluate the presence or absence of the GSTM1 gene from peripheral blood samples by a PCR-based method.

Results: The frequency of the GSTM1-null was 59.3% in the gastric cancer group and 45.5% in the control group. An increase in risk for gastric cancer was found among carriers of GSTM1-null genotype. The odds ratio (OR) was 1.752, with 95% confidence interval (CI) = 2.963 approximately 1.035.

Conclusions: GSTM1-null polymorphism was associated with genetic susceptibility of gastric cancer in Taiwan.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Age Distribution
  • Aged
  • Base Sequence
  • Case-Control Studies
  • Female
  • Gene Expression Regulation, Neoplastic
  • Genetic Predisposition to Disease / epidemiology*
  • Genotype
  • Glutathione Transferase / genetics*
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Polymorphism, Genetic*
  • Probability
  • Reference Values
  • Retrospective Studies
  • Reverse Transcriptase Polymerase Chain Reaction / methods
  • Risk Assessment
  • Sex Distribution
  • Stomach Neoplasms / epidemiology*
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / therapy
  • Survival Analysis
  • Taiwan / epidemiology

Substances

  • Glutathione Transferase
  • glutathione S-transferase M1