Blue rubber-bleb nevus syndrome: report of a case associated with osteoid osteomas

J Dermatol. 2005 Jul;32(7):589-93. doi: 10.1111/j.1346-8138.2005.tb00804.x.


Blue rubber-bleb nevus syndrome (BRBNS), or Bean's syndrome, is a rare angiomatosis characterized by multiple cavernous hemangiomas of the skin, mucosae and frequently of other sites. A 49-year-old male patient had been affected since birth by multiple angiomas localized in the skin, lips, oral cavity, cranial theca, and central nervous system; intrauterine rupture of angiomas in the right parietal lobe had caused partial hypotrophic paralysis of the left hemisoma. In addition to BRBNS, the patient was affected by three osteoid osteomas: this never-described clinical association is here discussed.

MeSH terms

  • Bone Neoplasms / pathology*
  • Brain Neoplasms / pathology
  • Hemangioma / pathology*
  • Humans
  • Male
  • Middle Aged
  • Mouth Neoplasms / pathology
  • Neoplasms, Multiple Primary / pathology*
  • Nevus, Blue / pathology*
  • Osteoma, Osteoid / pathology*
  • Skin Neoplasms / pathology*
  • Syndrome